Liver Cancer Projected to Double but Over Half Preventable

Obesity-related liver cancers are the fastest-growing cause of the disease.

At least 60% of liver cancers could be preventable, according to an analysis published Monday in The Lancet.

Liver cancer is the sixth most common cancer in the world, with around 870,000 cases in 2022. That’s projected to increase to 1.52 million cases in 2050, the new report found, if no changes are made.

The leading cause of liver cancer is viral infections, including the hepatitis B and C viruses. Hepatitis B infections — which are preventable with a vaccine — accounted for 39% of liver cancers in 2022. That’s expected to fall slightly, to 36.9%, by 2025. Hepatitis C accounted for 29.1% of liver cancers in 2022 and is also projected to fall, to 25.9%, by 2050.

The proportions of alcohol- and obesity-related liver cancers, however, are projected to rise in the next 25 years. Alcohol accounted for 18.8% of liver cancers in 2022, and that is expected to increase to 21.1% in 2050. The share of liver cancers caused by obesity-related disease is projected to increase from 8% to 10.8% by 2050 due to increasing rates of obesity, diabetes and high cholesterol and other metabolic risk factors.

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